i think it is #3
i hope this is !
climate change and agriculture are interrelated processes, both of which take place on a global scale. climate change affects agriculture in a number of ways, including through changes in average temperatures, rainfall, and climate extremes (e.g., heat waves); changes in pests and diseases; changes in atmospheric carbon dioxide and ground-level ozone concentrations; changes in the nutritional quality of some foods; and changes in sea level
macrophage is a type of white blood cell which is a phagocyte.
neutrophils are the most abundant white blood cell in humans and arise from granulocytes.
the substrate has changed shape because of the high temperature.
so your answer is a